The loo had been moved from the back wall to a couple of metres past the middle of the house before I bought my current house. Joists run the wrong way too.
The soil runs above the floor(hidden in a vanity unit, then a small bit of boxing) under the back of the bath, then into a 90 (91.5) about a foot of soil going down through floor then into another 90, through a supporting wall and then along the old kitchen ceiling and out through the wall. The kitchen ceiling was then lowered by about a foot to hide it.
I wouldn't personally be over the moon with the two elbows only a foot apart, sounds like a hot spot for blockages, but I've owned the house for nearly 15 years, even had it rented out for about 5 of those years and never a problem.