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Glycosyltransferase-like protein LARGE1 is an enzyme that in humans is encoded by the LARGE gene.

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  1. cr0ft

    Large Dogs or Small Dogs

    Help me settle a discussion my wife and I are having. Which make better pets??
  2. V

    LARGE house boiler sizing

    Hi Just started with a new firm...and they have decided that I am to size the boilers for the properties. Was not told this before I started and the old guy left. I have boiler sized for years with mears then stars ...then the whole house method.BUT the next 2 properties are 50 kw and 150kw...
  3. P

    Pricing up a large job

    I've got a job starting tomorrow, the job entails:- upstairs circuit 7 rads downstairs separate circuit 4 rads separate downstairs underfloor heating circuit approx 30m2 new 300l unvented cylinder new system boiler copper (£500 of) all new valves etc all new pipework first fix hot and cold...
  4. R

    Considering getting a large vertical radiator, any disadvantages?

    Hi, We have a 600mm x 1400mm SIngle Panel/Convector radiator in our hallway that is a reasonable size and may in the future be used as a dining area. We are having a new boiler and rads installed soon, and was considering getting a vertical rad to replace the old one, so it frees up a lot more...
  5. F

    Looking for help re good finish on large gap around bath

    Hi, i had a plumber in to fit a bath in my house. He fitted it up to the wooden bar the tiler used to start his tiling. As a result I now have a gap between the bath and the wall where the wood is exposed. I have looked in a few merchants for some kind of PVC strip to cover the wood but had...
  6. J

    Flues in large boiler cupboard

    I want to redo my kitchen and wanted your thoughts on whatto do with large boiler cupboard. The boiler is at a far left corner of thecupboard and there’s a lot of unused space to its right. However there are someflues in that unused space which are believed to contain asbestos. These flueswould...
  7. cr0ft

    Would you do a large job like a luxury kitchen installation for your parents?

    My folks have asked me to do a £12k kitchen installation for them soon. Was wondering what other people feel re doing big jobs like this for family. I'm a bit nervous as my dad is one of those who likes to tell people how to do their job!!
  8. D

    Unusual request

    Hi all im looking for some help I've got an old building that I would like to fit an old system like the used to have in churches and schools. Basically a pipe that flows round the area with no radiators just a large pipe maybe 50mm diameter. I am hoping that the boiler will also provide hot...
  9. M

    Boiler Affiliate Scheme/looking for a large engineer network

    Morning all We are shortly launching an online boiler repair and service business. We are looking for a company/affiliate scheme to send our leads to, or a company with a large network who we can use for our bookings. thanks
  10. S

    Replacing a large radiator with a small radiator

    Hi guys, I'm new to plumbing so please go easy! I'm replacing an old radiator which has started to corrode and leak with a new one which is slightly smaller. The problem I'm having is trying to find the right parts that allow me to extend the pipes enough to fit the original pipework. I bought...
  11. T

    Large baths, reinforcing floor

    Anyone had any experience of installing a large bath? (1800mm x 1100mm x 440mm) (Ancona Double Ended Bath) Customer is looking to get something like this & I have said that due to size of bath & larger water capacity that the floor underneath the bath would have to be reinforced! Would most...
  12. T

    Large sink waste required after removing waste disposal unit.

    I need to remove a waste disposal unit which was fitted in breach of the apartment regulations. Is there a conventional kitchen sink waste that would be large enough to cover the gap left by the removed wdu fitting? I have not actually yet seen the installation but expect the diameter of the...
  13. C

    Tap holes in acrylic bath are too large

    I have replaced 2 separate bath taps with a 2 hole mixer on an acrylic bath. The fixing centres are fine, but the holes are so big that the foam seal only just covers the holes. Consequently we get loads of water dripping through the holes when the shower is used. A bead of silicone round the...
  14. T

    12 rads on quite a large system - Vaillant 37 kw

    Just looked at a job. It's a very large house and is currently running a floor stander with DHW store. The customer wants a vaillant and as they have two bathrooms I recommended the 837 pro. There are twelve rads of various sizes on the system. I cant recall what vaillant say as the max amount...
  15. W

    Large securing bolts on fancy-schmancy taps.

    I've done hundreds of monoblocs but at least twice have come across - usually all singing and dancing - ones that have a securing bolt too big for the largest spanner in the monobloc set. Mine go up to '13' and have usually had to fight with pair of grips to get it sorted instead. I've heard...
  16. C

    Estimating large luxury houses

    Does anyone know a decent estimator? I'm trying too estimate the labor for a 14000 sq foot luxury house with 3.5 meter ceilings. Average time it takes to run a linear meter of Cast Iron would be a great start otherwise.
  17. S

    Can large header tanks be folded?

    I have heard that the large plastic header tanks can somehow be folded to get them in or out of a standard loft hatch. I need to get a large disused circular black plastic one out of my loft but although it is slightly flexible it seems far too stiff to be able to fold it. Is it possible, and...
  18. M

    Large Display Banners

    Hi Lads, Just incase any of you are thinking of this route, or have used this route before and find it beneficial, I got 5 of these banners made, we display them around about Glasgow area. The banner size is 6ft by 3ft and the 5 of them cost me about £120 - there of excellent quality and come...
  19. W

    Best method and toolsfor lifting large sections of solid board flooring?

    And pitfalls and perils to guard against .... I'm guessing circular saw set to correct depth carefully cut across joists and fix noggin to joists by cuts when replacing for extra support?
  20. A

    Large indirect (200 lire +) dual immersion vented cylinder.

    Does anybody make them, not having any luck with local suppliers?

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