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Glycosyltransferase-like protein LARGE1 is an enzyme that in humans is encoded by the LARGE gene.

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  1. B

    Toilet has large gap between it and tiled floor

    I have a potential issue with a toilet on a newly tiled floor and looking for some advice on acceptable tolerances and what to do. The back of the toilet sits at about 2mm from floor and the sides vary between 2mm - 16mm. It is a closed back on toilet base and approximately 190mm to 200mm from...
  2. thermostatguy

    Thermostat (manual, M30x1.5) does not fit on radiator (too large)

    Hi, I bought a M30x1.5 thermostat and was hoping to fit it onto the radiator (there is currently no thermostat attached), but it does not fit (the thermostat connector is too wide, see photos). Do I need an adapter or something, or a different thermostat? Thanks!
  3. G

    Shower tray large puddle at the back

    Our shower room has been replaced and finished last week. The shower is an 1800 tray with the drain at the front. On using the shower we are finding a puddle at the back right which is never going to drain as it appears the tray slopes backwards when checking the edges with a spirit level. This...
  4. F

    What is this lump of brass attached to the boiler pipe is please ?

    Hi everybody, I am new here! I am moving house but not yet arrived and trying to anticipate any problems. I took a picture of the gas boiler installation in the garage, it has a large brass object hanging off either the flow or return and I have not encountered one before, I hope someone here...
  5. D

    Shower panels. How to fill gaps around pipe holes that are too large

    So. I have managed to fit shower panels directly over tiles. My issue however is I had to cut the shower panels more than I had liked around where the water pipes come in due to the metal fixings that attached them to the wall. This now means when I screw the pipe collars back over the pipes...
    • DPeter
    • Thread
    • america around holes large panels pipe shower usa
    • Replies: 2
    • Forum: USA
  6. S

    Boiler Sizing - Large 3 Bed House

    Hi All, Hoping to get some sound advice regarding combi boiler sizing for a large 3 Bed House. We are refurbishing the house and plan to strip out the old boiler and pipework from the loft to relocate to the kitchen / diner whilst also renewing all copper pipework and installing new radiators...
    • Sjrogers1
    • Thread
    • america boiler house large sizing usa
    • Replies: 6
    • Forum: USA
  7. OllyLennox

    Large object stuck quite deep in drain

    Hi there, We have a shower unit which normally has a peg-shaped trap in the waste to prevent large objects going down the waste pipe. However when it gets clogged up with hair etc. my other half tends to just pull it out (and leave it out) so lo and behold, something large has gone down there...
    • OllyLennox
    • Thread
    • america drain large quite stuck usa
    • Replies: 2
    • Forum: USA
  8. M

    CH change: large house & 2 boilers

    Hello I am renovating an Edwardian property with a two-storey extension that was built 10 years ago and currently has two boilers individualy covering original house & extension as below: Original house (system boiler, 10-15 years old) 4 ground floor rooms all with wet UFH 4 first floor...
    • Mjward
    • Thread
    • america boilers change house large usa
    • Replies: 29
    • Forum: USA
  9. T

    Radiator change on large pipework

    Hi, I have 1 radiator in the house where the radiator is on a different diameter pipework. The rest of the house is 15mm but this could be 22mm, I'm not sure. I want to replace this radiator with a new one and if possible I dont want to disturb the original parkay flooring. What do I need to...
    • thegudge
    • Thread
    • america change large pipework radiator usa
    • Replies: 6
    • Forum: USA
  10. J

    Can airtap ATI66 fill a large tub, if not, qhat is viable alternative

    My client has a system running off of an airtap ATI66 amd cannot fill her large tub with hot water. How could I adapt something to make this work. Maybe an inline on-demand heater specifically for the tub? Any ideas or input would be greatly appreciated.
    • Jon-Paul
    • Thread
    • alternative america large usa
    • Replies: 1
    • Forum: USA
  11. D

    Tiler mistake with shower - large gap between tiles and ceiling

    Hi all Having a bit of a mare; some of you may recall but after having my last shower installation botched (but thankfully getting my money back after threatening to make a court claim), I've had another botch job with fitter #2! (found him on trustatrader with decent reviews but I guess...
    • DIYnoob
    • Thread
    • america between ceiling gap large shower tiler tiles usa
    • Replies: 13
    • Forum: USA
  12. F

    Large UFH with electric boiler

    Have a large ufh job to do 250m2 with low profile boards, 12mm pipe, 150mm spacing. Customer does not want gas in the house so wants an electric boiler. Unvented cylinder will be direct so boiler will only be running ufh. 2 manifolds to be installed 3 phase will be installed, but this means...
  13. D

    Gas pipe work long run from Gas meter in large property

    I am new gas safe and met hard situation when I did gas safety check on large property with 3 acre site. The property is old and large size, installed two 30KW heat only gas boiler to supply CH and DHW, range cooker and gas hob. I was be told the meter is installed at the entrance of the...
  14. J

    Unusual large water tank, considerations

    Hi Guys I'd like your thoughts on this. Customer has a 3 bar whole house shower pump and also an aqua lisa digital shower. Upon replacing the pump I noticed the water tank is only 50 gallons. It really should be 80-100 gallons? Its a 3 story town house with basement and two bathrooms...
    • Jones82
    • Thread
    • america large tank unusual usa water water tank
    • Replies: 11
    • Forum: USA
  15. J

    Advice on optimal system for large house?

    I am looking for advice on the best boiler system for my home. It is currently: a 4-bedroom mid-terrace period house of stone construction 1 toilet on ground floor 1 bathroom with bath and electric shower on 1st floor 28kw combi boiler fitted in kitchen 2000 sq. ft. with fairly high ceilings...
  16. D

    large property several plumbing jobs

    Based in West Yorkshire (Bingley) looking for a bathroom fitter. Several jobs at the property: 1) refurbish small downstairs cloakroom 2) refurb ensuite 3) reconfigure existing bathroom to bedroom with ensuite 4) reconfigure existing bathroom and separate toilet into bathroom
  17. 5

    LARGE HEAT ONLY BOILERS

    Looking to get a 40kw or 42kw heat only boiler for a largish house. already done heat loss to these values. was going to use and pressurise with external expansion vessel. Vaillant tech suggested they had a boiler to suit but i cannot find it? Anyone know if they do one ( it is for domestic use)...
  18. K

    Large limescale deposits

    When I bought my house 12 years ago there was a Scalemaster electrolytic inhibitor installed. Over the last few years the quality of the water (most noticeable in the kettle) has gotten worse so 6 months ago I replaced the Scalemaster and at the same time replaced my 5 year old dishwasher...
    • Kregler
    • Thread
    • america calcium large limescale usa
    • Replies: 2
    • Forum: USA
  19. R

    Is my boiler large enough?

    Hi all Last year we renovated the house we now live in. It didn't have any central heating so we had an intergas boiler fitted. Only after it being installed we realised the boiler was the HRE 24/18 (the guy who installed is intergas certified and had installed boilers for family as he is a...
    • Roberto Flint
    • Thread
    • america boiler enough large usa
    • Replies: 0
    • Forum: USA
  20. S

    Large gap discovered when resealing shower tray

    I have encountered a problem. My shower tray was leaking and I found out it was because the tray was flexing and causing a gap at the seal. I thought this would be an easy fix and have taken the seal off. Turns out this is not the case as the gap between the seal and the tiles is about 1cm tall...
    • Stewstew
    • Thread
    • america gap large sealant shower shower tray tray usa
    • Replies: 5
    • Forum: USA
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