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bodies
Inclusion bodies are aggregates of specific types of protein found in neurons, a number of tissue cells including red blood cells, bacteria, viruses, and plants. Inclusion bodies of aggregations of multiple proteins are also found in muscle cells affected by inclusion body myositis and hereditary inclusion body myopathy.Inclusion bodies in neurons may be accumulated in the cytoplasm or nucleus, and are associated with many neurodegenerative diseases.
Inclusion bodies in neurodegenerative diseases are aggregates of misfolded proteins (aggresomes) and are hallmarks of many of these diseases, including Lewy bodies in Lewy body dementias, and Parkinson's disease, neuroserpin inclusion bodies called Collins bodies in familial encephalopathy with neuroserpin inclusion bodies, inclusion bodies in Huntington's disease, Papp-Lantos inclusions in multiple system atrophy, and various inclusion bodies in frontotemporal dementia including Pick bodies. Bunina bodies in motor neurons are a core feature of amyotrophic lateral sclerosis.Other usual cell inclusions are often temporary inclusions of accumulated proteins, fats, secretory granules or other insoluble components.Inclusion bodies are found in bacteria as particles of aggregated protein. They have a higher density than many other cell components but are porous. They typically represent sites of viral multiplication in a bacterium or a eukaryotic cell and usually consist of viral capsid proteins.
Inclusion bodies contain very little host protein, ribosomal components or DNA/RNA fragments. They often almost exclusively contain the over-expressed protein and aggregation and has been reported to be reversible. It has been suggested that inclusion bodies are dynamic structures formed by an unbalanced equilibrium between aggregated and soluble proteins of Escherichia coli. There is a growing body of information indicating that formation of inclusion bodies occurs as a result of intracellular accumulation of partially folded expressed proteins which aggregate through non-covalent hydrophobic or ionic interactions or a combination of both.
After my recent threads on the horrondous plumbing ive have carried out in theprocess of having an extension done with the plumber who i hasten to add stll hasnt shown me how he arrives at nearly double the original price given.
Anyway the big prob ive got now is the newly installed toilet...
Muscle750
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Hi
As a newly qualified plumber I am looking at joining a professional body (competent person scheme etc). There are a number of bodies (CIPHE. APHC etc) all extolling their own virtues. What bodies would the membership suggest I look at joining and why ?
Steve
Sanke
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I have a stopcock thats letting by in the closed position and would like to change to 1/4 turn ceramic. Problem is there is no flexibility in the pipe (only four inches from ground level and same where it goes into wall) to allow me to remove old stopcock.
Can you get service packs for what...
If you wish to extend your range of work does it matter which certification body you go through.
i.e. I done my current ACS at a ConstructionSkills (CITB) centre and I now wish to add another element. Do I have to be assessed at a ConstructionSkills place or can I go through another body (BPEC...
Hello,
Hope you can advise. I currently work full time in the motor trade but have always wanted to be in the plumbing trade!
I am unable to give up work due to needing to be able to support my family!
Any way i would like to go self employed as a plumber i have found a local course that i can...
ward
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Any body doing any bottling/jaming of the fruits etc coming into season?
Just done 13 jars of wild plum jam, 4 jars of of wild plum and nectarine jam, 4 1 ltr kilner jars of sliced nectarine's in syrup, to add to the collection of jams chutneys, and fruit in kilner jars
In a couple of...
Having just completed City & Guilds 6129 my friends and family have all been saying to me "so you're CORGI registered now then".Clearly I know I am unable to touch gas legally, and don't want to until I'm able to progress to the relevant qualification/experience.
The worrying thing is that in...
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hi fellas, been a little busy last few days, just popped in to see if anyone has got any example questions for the ENVIONMENTAL AWARENESS exam, any help will be very much appreciated thanx,only 2 exams to go.......cheers.
ste b
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ECONOMIC PRESSURES RAISE FEAR OF COWBOY OPERATORS
With the economic downturn likely to result in a growing number of redundancies, industry bodies are warning that more people may be tempted to look to the plumbing trade as a potential money earner. There is concern that there...
uug197h
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hi guys.
just a few little problems that i would like a second oppinion on.
1) went to an office block today and they had 1 rad that was piping hot and the couldnt turn it off with the TRV and the other rad was the opposite and couldnt be turned on with the TRV.
would i be right to think...
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Thursday Mar 13
The Plumbing Industry Alliance, a body which represents most of the industry’s leading associations, is looking to rally support for its ongoing campaign against ‘rogue trainers’ - unregulated training schools that charge students ‘over the top’ fees.
Training schools...
uug197h
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