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Argatroban is an anticoagulant that is a small molecule direct thrombin inhibitor. In 2000, argatroban was licensed by the Food and Drug Administration (FDA) for prophylaxis or treatment of thrombosis in patients with heparin-induced thrombocytopenia (HIT). In 2002, it was approved for use during percutaneous coronary interventions in patients who have HIT or are at risk for developing it. In 2012, it was approved by the MHRA in the UK for anticoagulation in patients with heparin-induced thrombocytopenia Type II (HIT) who require parenteral antithrombotic therapy.Argatroban is given intravenously and drug plasma concentrations reach steady state in 1–3 hours. Argatroban is metabolized in the liver and has a half-life of about 50 minutes. It is monitored by PTT. Because of its hepatic metabolism, it may be used in patients with renal dysfunction. (This is in contrast to lepirudin, a direct thrombin inhibitor that is primarily renally cleared).

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  1. A

    Acova 4 column rad bleed valve

    Hi there I have a 4 column rad and can’t locate the bleed valve. Rad has been warm and not hot for quite some time and wanted to let out the air but not sure how. Please see pics attached and let me know if I’m missing something? thanks.
    • ARich87
    • Thread
    • acova america bleed bleeding column rad radiator valves usa valve
    • Replies: 2
    • Forum: USA
  2. Bogart

    Acova steel column radiator

    I am wanting to switch the feed from the bottom to the top of the rad. Obviously I will need to switch the bottom and top bushes around. Here is my dilemma are they LH or RH threads. I have tried to undo in both directions and cannot shift it. The bushes are at the opposite end from the bleed...
  3. Robert Tyrrell

    Acova radiators

    I fitted a few of these about a fortnight ago for a customer of mine and although there's plenty of water (Bled the system a few times) two of them are getting warm, but not hot, and one remains cold. [They] seem to think that the radiators might be installed the wrong way around. Is this...
  4. L

    Acova Radiators

    Hi all , i have an acova radiator in my dinning room 4 column type, about 1200mm wide and 600 mm high,been in for few years, but never realy got hot , done all the usual bleeding,balancing on the system,now i have just been looking and the feed to the rad is not opposite the air vent,after much...
  5. A

    Acova Column Radiator Failure

    Hi Folks I am wondering if anyone has experience of something similar? I installed a new central heating system in my flat approx 5.5 years ago. It was a new combi-boiler, polypipe pipework, and 8 Acova column style radiators. I put inhibitor in the system. Recently I noticed that the...
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