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Icos Corporation (trademark ICOS) was an American biotechnology company and the largest biotechnology company in the U.S. state of Washington, before it was sold to Eli Lilly and Company in 2007. It was founded in 1989 by David Blech, Isaac Blech, Robert Nowinski, and George Rathmann, a pioneer in the industry and chief executive officer (CEO) and co-founder of Amgen, Icos focused on the development of drugs to treat inflammatory disorders. During its 17-year history, the company conducted clinical trials of twelve drugs, three of which reached the last phase of clinical trials. Icos also manufactured antibodies for other biotechnology companies.
Icos is famous for tadalafil (Cialis), a drug used to treat erectile dysfunction. This drug was discovered by GlaxoSmithKline, developed by Icos, and manufactured and marketed in partnership with Eli Lilly. Boosted by a unique advertising campaign led by the Grey Worldwide Agency, sales from Cialis allowed Icos to become profitable in 2006. Cialis was the only drug developed by the company to be approved. LeukArrest, a drug to treat shock, and Pafase, developed for sepsis, were both tested in phase III clinical trials, but testing was discontinued after unpromising results during the trials. Eli Lilly acquired Icos in January 2007, and most of Icos's workers were laid off soon after. CMC Biologics, a Danish contract manufacturer, bought the remnants of Icos and retained the remaining employees.

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  1. D

    Ideal Icos HE12 constant F L Code

    Folks Me again I am at my wits end. I want to replace the boiler but I am on my backside and cannot afford to. I have been getting an intermittent F L Code. For around a year. I've had an engineer out 4 times. In that time boiler has had a new PCB, new electrodes, new gaskets, new...
  2. P

    Ideal Icos 18 Boiler sparked - PCB gone?

    Hi All I'd appreciate advice on what the potential issue could be with this boiler. Its a heat only Ideal Icos 18 fitted to an open vent system It had been switched off during the summer and had occassionally been used to heat water. Turned it one a few days ago and I could smell some...
  3. S

    IDEAL icos he30 boiler Opentherm

    Hi all, I have an IDEAL icos he30 boiler. I understand that this is not Opentherm capable, as it is quite old. But I was wondering if there is a way to do this, as I would like to use a Tado or Nest thermostat on it? Any advice would be appreciated. Thanks
  4. N

    IDEAL ICOS HE24 intermittent LF code

    Hi All I know I know ... another HE24 LF code problem. Fix is replace boiler ;-) My problem is slightly different to other posts I've been reading in that the boiler works fine for 95% of the time. It will often go a few days then we get the LF code. We hit reset and it always always...
  5. D

    Ideal ICOS HE12 DESPERATE FOR HELP

    Hi All I tried posting this already and lost post so here goes again. I'll start from the beginning so please bare with me. Few Months ago I was getting intermittent heating with occasional flame error code on my ICOS HE12. British gas engineer came out when the system was working and...
  6. JohnZZ

    Ideal ICOS HE12 boiler leaks

    It starts to leak clear water when both hot water and central heating are running. I opened the sump cover, there was a puddle in there. I thought the condensation s-trap might be clogged. So I clear that out. It was fine for one night and the next morning, it started to leak again. Any...
  7. U

    Ideal Icos HE30 boiler start-up sequence

    My Ideal Icos HE30 boiler has been reliable starter since its installation 12 year's ago. It has been serviced every year since by the original installer. Today the boiler failed to fire though the thermostat is calling for heat. I replaced the batteries in the thermostat. I turned the...
  8. C

    Ideal Icos HE24 pump keeps failing

    Hey guys I have a re-occurrent fault with the boiler in my rented house. The boiler has had many problems and been "fixed" by several engineers but no matter what, the pump always seems to fail and then needs replaced. It's been replaced about 4 times in the last couple of years ( once within a...
  9. U

    Icos He30 combi boiler resolution L9/H9 fault codes

    My boiler is an Ideal Icos HE30 boiler. This supplies the central heating and a separate heat store - in other words a big cylinder - for domestic hot water. It is not a combi boiler. The boiler is 10 years old and it has been serviced by the original installer each year since installation. It...
  10. S

    IDEAL ICOS HE 15 L&F Troubleshooting Help Required

    Hi, I have a an IDEAL ICOS HE 15 boiler that was fitted in 2005 to a new build property and in general it's been pretty reliable over the years. However the last few weeks it started to show an L&F fault, which a reset normally clears for a week or so. However yesterday morning I woke to the L&F...
  11. U

    URGENT Hi all. CH fails to work on timed / auto. Constantly seems to cavitate.

    Ideal Icos HE18. Y plan. Ok when on constant. Set to auto and when firing up of an evening, banging and clattering. Any suggestions pls?
  12. king of pipes

    Ideal icos 6 years without a service

    Went to this boiler today as the property is being sold and the owners have had a offer , the boiler was nearly jumping off the wall when firing up:eek:đź’Ą, stripped it down to find the heat exchanger blocked solid with aluminium scale not allowing a smooth flow of products through bit of tlc and...
  13. M

    Ideal Icos HE24 LF. code

    Good morning, Our boiler has started to fail after 14 years. Given the apparent reputation of this particular model, I think it's done rather well! The current fault has become progressively worse over a few weeks. The boiler is now igniting but then shows LF. within a few minutes. As the...
  14. B

    what should Ideal Icos boiler Status read

    can anybody tell me what the status on the front of a Ideal Icos boiler should read when it is on hot water as when mine is on it says status C but everything seems to work ok
  15. phil hair

    best boiler to replace ideal icos 15

    sorry to ask the same old questions again. Im due to replace an icos 15 he and im looking for your valued opinion. I fit a lot of logic plus combi's , but the heat only requires a wire to the pump from boiler (for the pump over run) I think i read somewhere that this is not required anymore...
  16. J

    Ideal Icos HE35 Condensate Pipe flow?

    Just recently I have found a small flood under my kitchen sink, and found that there is a build up of water from the pipe under the sink from the condensate pipe to flow into the drain. There is nothing wrong with the drain, as the pipe is connected to the main sink drain and the water flows...
  17. J

    Ideal Icos He30 LE code, Emc filter?

    Hi guys Been to regular of mine, original call was pointing towards low pressure and LE Code, he topped it up and got the boiler working for a day or so but now it is absolutely dead. I've been round and tested it and was leaning towards overheat stat but getting no voltage to it, started...
  18. C

    Icos he18 l and f code

    Hi all. Hope you can help. Been to look at an ideal icos he 18 l & f code. Done everything from the flow chart and changed the flame detection probe. Contacted ideal and they're advice was to boil the kettle a few times and flush the heat exchanger to clear the aluminium oxide build up. Ive...
  19. S

    No sign of life - ideal ICOS 15he

    Hi guys, Just got back from a neighbours house who’s ideal ICOS 15he showing no sign of life. Not lights nothing. Checked fuse spur and working fine. 240v to boiler . 240v to on/off switch. Checked short circuit on the on/switch and came back fine. I’d say main pcb has gone but how do you...
  20. A

    Icos no display, not working

    Hi everyone I went to a job this morning for a plumbing repair and the customer said can I have a look at the boiler too. Its an icos (2nd this week). The boiler is not working, nothing on display. It has power to it. Fuse is OK. Do I go with just the pcb or pcb and user display? Thanks
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